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Studies demonstrate that LPS activates adipose tissue macrophages via TLR4 receptors, promoting the release of proinflammatory cytokines such as TNF-, which in turn induces excessive lipolysis in adipocytes, generating large quantities of free fatty acids (FFAs) (51)

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doi: 10.1016/j.xcrm.2025.101928 50 RashmiRJayachandranKZhangJMenonVMuhammadNZahnerMet al

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Abnormal DNA methylation typically occurs in the early stages of tumorigenesis and can provide new insights for the early detection of LC

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(Current PI for Wegovy/Ozempic)

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