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These concerns were initially based on biological evidence indicating that the incretin system and the GLP-1-receptor might play a role in the development of cholangiocarcinoma [5,6,7], and further highlighted by an observational study using data from the UK Clinical Practice Research Datalink [8] showing that use of DPP4 inhibitors, compared with other second- or third-line glucose-lowering drugs, was associated with an increased risk of cholangiocarcinoma (HR 1.77 [95% CI 1.04, 3.01])

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PubMed laboratory research record [PMID: 25774339] PubMed record related to this compound for laboratory literature review

Mix with water, cold juice, or smoothies

McGovern AS, Hamlin AS, Winter G