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Additionally, NADPH is used in the visual cycle of photoreceptors for the conversion of the isomerized light-absorbing chromophore retinal back to its native state 32

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For example, metformin-treated T2DM patients with elevated levels of Bacteroides fragilis in the gastrointestinal tract, whose metabolite glycoursodeoxycholic acid (GUDCA) is involved in inhibiting FXR signaling (Sun et al., 2018)