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PMID: 35711368

However, the SmPC does not support accelerated dose escalation after treatment interruptions

Symptoms Symptoms of EDS vary by type and may include: Back pain Double-jointedness Easily damaged, bruised, and stretchy skin Easy scarring and poor wound healing Flat feet Increased joint mobility, joints popping, early arthritis Joint dislocation Joint pain Premature rupture of membranes during pregnancy Very soft and velvety skin Vision problems Exams and Tests Examination by a health care provider may show: Deformed surface of the eye (cornea) Excess joint looseness and joint hypermobility Mitral valve in the heart does not close tightly (mitral valve prolapse) Gum infection (periodontitis) Rupture of intestines, uterus, or eyeball (seen only in vascular EDS, which is rare) Soft, thin, or very stretchy skin Tests to diagnose EDS include: Collagen typing (performed on a skin biopsy sample) Collagen gene mutation testing Echocardiogram (heart ultrasound) Lysyl hydroxylase or oxidase activity (to check collagen formation) Treatment There is no specific cure for EDS