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The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
This coordinated action results in faster healing, reduced scar tissue formation, and improved functional recovery compared to single-peptide approaches
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BPC-157 acts via VEGFR2-ERK1/2 and nitric oxide pathways to promote angiogenesis and fibroblast activity, while TB-500 (the 43-amino-acid synthetic analogue of Thymosin Beta-4) functions primarily as an actin-sequestering protein that regulates G-actin/F-actin dynamics, cell migration, and endothelial differentiation
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