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These effects are dose-dependent, meaning the faster the medication hits your system, the more pronounced they may be during the initial absorption phase

Conversely, adding an SGLT2i to a GLP-1RA did not yield a statistically significant further reduction in HbA1c (SMD 0.11%), suggesting that the glycaemic benefit of combination therapy is predominantly driven by the GLP-1RA component

This reduces the risk of introducing bacteria to the injection site

Hypoglycemia was reported in 3.4% of all GLP1 exposures reported to one poison center, and patients should be counseled on signs and symptoms of hypoglycemia if being monitored at home

PMID: 1328231