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Shenoy says
This complexity is reinforced by evidence for metabolon organization, where enzyme interactions, substrate channeling, and intracellular compartmentalization contribute to pathway behavior (Winkel, 2004)
Nat Commun 10 , 924 (2019)
[9] [10] The key difference lies in their approach: Trulicity provides an external source of GLP-1 receptor stimulation with additional effects on appetite and gastric emptying, whilst Januvia preserves the body's own incretin hormones by preventing their breakdown
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