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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration

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TB-4, in parallel, promotes angiogenesis by facilitating endothelial cell migration and organization via actin dynamics [11]

The weight continued to increase due to lack of exercise and going to physical therapy multiple times a week due to previous injury