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Most surgical guidelines recommend stopping semaglutide injections 2 to 4 weeks before elective surgery to allow gastric function to return to baseline
Dosing a short-acting GHRH analog (sermorelin, no-DAC CJC) at bedtime stacks the peptides pulse on top of the natural one, amplifying it rather than fighting it
The overall cost of therapy with tirzepatide topped $17,500, while the cost for semaglutide was almost $23,000
For patients comfortable with manual injection, compounded options offer comparable efficacy at lower cost (Fitch et al., Obesity, 2024)
New medications are on the horizon, like those combining GLP-1 with other hormones (like amylin), oral versions that could compete with injectable semaglutide, and even triple-action drugs
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