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Shortage of vitamin B12 can also result in pernicious anemia, which may be due to impaired absorption of vitamin B12 caused by a lack of intrinsic factora substance necessary for the absorption of vitamin B12 in the intestines

Total daily doses of 300 mg, 450 mg, or 600 mg can reduce pain by more than 30% if the patient can tolerate the side effects of dizziness, somnolence, dry mouth, weight gain, and peripheral edema, especially at 600 mg

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