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Biomarkers including HbA1c, fasting insulin, lipid profiles, and body composition measurements provide the quantitative feedback needed to determine whether the combined approach is producing the intended metabolic effects, whether adjustments to formulation or dosing are needed, and whether the balance between the two therapies remains appropriate as a woman's physiology evolves through and beyond the menopausal transition
A1C Reduction GLP-1 agonists are generally more effective than SGLT2 inhibitors at reducing A1C, a critical measure of long-term blood glucose control
It felt very mild overall
Providers should schedule more frequent follow-up visits during the initial combination period to identify adverse effects early and adjust treatment as needed
The predefined protocol of the present study was registered in the International Prospective Register of Systematic Reviews ( PROSPERO : identifier CRD42023469511)
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