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Front Cell Neurosci 9:392 Kennedy S, Lam R, McIntyre R, Tourjman S, Bhat V, Blier P, Hasnain M, Jollant F, Levitt A, MacQueen G, McInerney S, McIntosh D, Milev R, Mller D, Parikh S, Pearson N, Ravindran A, Uher R (2016) Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder