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Using various biochemical and biophysical approaches, we demonstrate that Syn WT engages in functional interactions, whereas C-terminal acidic tail truncated Syn 1103 and S129-phosphomimicking ( S129E ) mutant are reactive, displaying broad, non-functional aberrant binding and impairing chaperone-mediated refolding
In controlled laboratory research environments, glutathione is extensively studied for its central role in cellular redox balance, antioxidant defense systems, and detoxification-related biochemical pathways
Mitochondrial quality and quantity control: Mitophagy is a potential therapeutic target for ischemic stroke
Lack of long-term studies, except for TA, is a deterrent for determining their optimum dosage and delayed side effects
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