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Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

BMC Medicine

Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means

Unlike in the pancreas, the gene product, (pre)proglucagon, is processed here to release the two glucagon-like hormones, GLP-1 and GLP-2, 2 whereas the glucagon sequence is buried in an N-terminal fragment of proglucagon called glicentin

10.1007/s13668-024-00560-w 55