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Preclinical studies suggest GLP-1 agonists may reduce synovial macrophage infiltration and decrease production of matrix metalloproteinasesenzymes responsible for cartilage degradation in RA

About half of the patients with PCD start to see symptoms when they are very young, between three months and two years old

The most frequently reported side effects across all tirzepatide clinical trials are gastrointestinal, including nausea (reported in 12-29% of participants depending on dose), diarrhea (12-16%), constipation , and decreased appetite

Glucagon Inhibition: It reduces the secretion of glucagon, a hormone that raises blood sugar levels, thus preventing excessive glucose production by the liver