Copyright 2013 Elsevier BV, Inc
Synopsis NRF2 utilizes the CBP/p300 coactivator to drive glutathione synthesis, yet this functional interaction is not required to support non-small cell lung cancer proliferation
Millar DM, Ow K, Paul C, Russell P, Molloy P, Clark SJ (1999) Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer
Samenvatting Glutathion is een krachtige antioxidant die door het lichaam wordt geproduceerd en die vrije radicalen neutraliseert en beschermt tegen oxidatieve stress
While classical serum protein biomarkers (e.g., CA19-9 for diagnosis/monitoring, CEA for postoperative monitoring) are clinically established, non-protein biomarkers such as circulating tumor DNA (ctDNA) [79, 80] RNA signatures (e.g., miR-21) [81] metabolites [82, 83] and circulating tumor cells (CTCs) [84] show significant potential for early detection, prognostic evaluation, and treatment selection (Table 1)