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PLGA is a hydrophobic polymer, which is more suited to encapsulate hydrophobic rather than hydrophilic agents via two general methods 4 : (1) Nanoprecipitation, in which PLGA and agents to be encapsulated are dissolved in a good solvent and then co-precipitate into nanoparticles upon addition into a non-solvent for both
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In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state
FIGURE 7 3.7 Catalase Response Unlike any other antioxidant enzymes evaluated in this study, the CAT response for non-exposed groups 1 to 3 was distinctively different
This landscape illustrates both the promise and challenges: multiple valid targets exist, but translational failures have been common
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