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6,7 Conversely, nonsurgical periodontal therapy such as scaling and root planing have demonstrated an increase in glutathione levels, suggestive of an improved antioxidant status and reduction in oxidative stress, perhaps partly due to a reduction in the proteolytic activity of bacteria and reductions in inflammation

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Targeting early exons or conserved functional domains is generally preferred for gene knockout studies because such modifications are more likely to disrupt gene function [48, 103]

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Aging Cell 21 , e13662 (2022)