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ALA improves insulin sensitivity and can be beneficial in managing Diabetes, specifically blood sugar and lipid levels

The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

Current Rheumatology Reports , 26 (12), 403413

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In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached