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Suggestive as these changes clearly are, they likely represent only a small minority of the full breadth of pathogenically relevant changes in this dataset, many of which may involve proteins with as-yet poorly explored functions

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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

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