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A few limitations exist within this study
These effects were mitigated by inhibition of MMP-9 or vascular endothelial growth factor (VEGF), indicating that MMP-9 and VEGF contribute to TJ disruption in ischemic conditions
In the Phase 2 trial, participants on the 12mg dose of retatrutide lost up to 24.2% of their body weight over 48 weeks
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