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Frequency, consistency, and ease of passage
For context, the toxic dose is estimated at roughly 22,500 mg, compared to a typical weekly dose of about 6 mg
This escalation approach is standard across GLP-1 class compounds and serves to improve gastrointestinal tolerability
This leads to prolonged calcium presence in the cytosol, which can impair the relaxation phase of muscle contraction and lead to sustained low-force contractions
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