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The effects are produced mainly by the increase in nitric oxide (NO), cyclic AMP (cAMP), mitogen-activated protein kinases (MAPKs), matrix metalloproteinases (MMPs), angiogenic growth factors like vascular endothelial growth factor (VEGF) and upregulating the expression of endothelial-B receptor (ET-B) [12]

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216 Furthermore, a randomized, double-blind, placebo-controlled trial in 65 hemodialysis patients reported that taking 1,200 mg, but not 600 mg, of CoQ10 daily for four months decreased oxidative stress (as indicated by a decrease in F2-isoprostanes)