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Neurobiol Learn Mem (2010) 93(4):54653

Patients who skip the escalation or increase doses too quickly are significantly more likely to experience severe nausea, vomiting, and other gastrointestinal side effects that may lead them to discontinue treatment entirely

H, Marinova M, Kaasa S, Stieber C, Conrad R, Radbruch L, Mcke M: A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project