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Climate Change Committee

Kalia LV, Lang AE

Clinical treatment strategies 4.2.1

In the phase 3 study REDEFINE 1 (about 3417 adults with obesity without diabetes, 68 weeks), the cagrilintide + semaglutide combination produced a mean weight reduction of 20.4% , versus 11.5% for cagrilintide alone, 14.9% for semaglutide alone and 3.0% for placebo

They are categorized into six subcategories based on the carbon atoms connected to the C ring by the B ring, as well as the degree of unsaturation and oxidation of the C ring: flavanones, flavones, isoflavones, flavonols, chalcones, and anthocyanins (Hostetler et al., 2017)