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Interestingly, in patients who went on to develop PACS, there were notable reductions in the total EVs levels of the MPs Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c), Voltage-Dependent Anion Channel 1 (VDAC-1), and humanin, along with increased levels of Sterile Alpha and TIR Motif-Containing Protein 1 (SARM-1)