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The most consistently documented side effect of excessive B12 is dermatological reactions, particularly acne-like eruptions and rosacea flare-ups
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Individuals with MTHFR polymorphisms or baseline methylation impairments may want to monitor homocysteine levels if using 5-Amino-1MQ beyond 12 weeks
Normal B12 ranges typically fall between 200-900 pg/mL, though functional B12 status is better assessed by methylmalonic acid (MMA) and homocysteine levels
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