Concurrent Medications Concurrent medications can significantly influence the duration that a B12 injection lasts in the body
Vitamin B12 shot side effects Most people tolerate vitamin B12 injections well, but possible side effects include: Mild: soreness or redness at injection site, mild diarrhea, nausea, headache, itching Rare but serious: allergic reactions (rash, swelling, difficulty breathing), low potassium (hypokalemia), dizziness or heart rate changes Get emergency medical help if you have signs of an allergic reaction to Vitamin B12: hives
On the other hand, chronic kidney disease causes fast excretion of cobalamin through urine, resulting in low levels
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David Sinclair on Informational Theory of Aging