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Notably, injection site discomfort with GHK-Cu tends to be more frequent than with other peptides, due to the copper component

Within the GHSR1a-MC3R dimer, the GHSR1a inverse agonist SP-analog eliminates amplification of MC3R signaling (Rediger et al., 2011), an effect likely due to the dependence on GHSR1a constitutive activity

Finally, the use of L-carnitine (10-20 mg/kg body weight given as a slow bolus injection) is approved by the US FDA to treat L-carnitine deficiency in subjects with ESRD undergoing hemodialysis (76)

This study confirms what we are seeing clinically

The most common side effects are injection site reactions such as swelling, rash, or inflammation