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In contrast, tirzepatide is the first dual-incretin mimetic peptide to be approved for the treatment of type 2 diabetes and chronic weight management
Additionally, excluding patients with a diagnosis of any psychiatric diseases within one year before or one month after the index date may not be sufficient to avoid bias
Additionally, DPP4 inhibitors also exert vascular protective properties, including anti-inflammatory and anti-atherosclerotic effects and the ability to induce vascular relaxation (179, 180)
In SURPASS 4 The risk of suffering from any major adverse cardiovascular event MACE-4 and MACE-3 (including myocardial infarction, stroke, hospitalization for angina, and all-cause death) with the highest dose of tirzepatide (15 mg per week) has been estimated at 050 (026095), which was intended to provide initial proof of the cardiovascular safety of tirzepatide [2, 5]
After 16 weeks, patients on Rozebalamin had experienced a 43% lower decline in ALSFRS-R scores, indicating a significant slowing in disease progression, compared with a placebo
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