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In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis

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Adipocyte energy expenditure published animal models have explored NNMT inhibition with 5-Amino-1MQ in diet-induced-obesity rodents, examining adipose-tissue mass, energy expenditure, and metabolic markers