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[36, 37] Unlike conventional hypodermic needles, microneedle systems create transient microchannels that bypass the stratum corneum, enabling efficient transdermal transport of a wide range of molecules, including peptides, proteins, and small drugs, without reaching nerve-rich deeper layers and thus minimizing pain and risk of infection [38, 39]

Targets the GHS-R1a (ghrelin) receptor Same receptor as ghrelin, located in the pituitary and hypothalamus

This neuroprotective dimension makes it relevant not just for injury recovery but for patients managing neuropathic pain

Yang L, Zhu H, Li M, Yu Q

The same color scheme was used to visualize the water probes