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Below BMI 27, prescribing is off-label, and Second Nature doesnt prescribe medications to anyone with a BMI of below 27

Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)

doi: 10.1038/s41576-025-00907-1 323 TianG.ChenH.JiangR.ZhangC.LuX.WangX.et al

In this study, a mean weight reduction of 7.8 percent, 9.3 percent, and 12.4 percent was reported at 6, 12, and 36 mg, versus 2.1 percent under placebo