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Feeling cold during retatrutide treatment is most plausibly linked to rapid or substantial weight loss and reduced caloric intake , rather than a direct pharmacological effect on thermoregulation

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Paschou, E

This dual action: Enhances insulin sensitivity beyond GLP-1 alone Promotes more substantial appetite suppression Improves metabolic function through multiple pathways May lead to greater fat loss, particularly visceral fat Think of it as addressing weight loss from two complementary angles rather than one

Patients should verify that their vials arrive cold and should transfer them to refrigeration without delay