GLP-1 receptor agonists like semaglutide and tirzepatide work through an entirely different mechanism: they activate incretin receptors in the pancreas and brain to reduce appetite, slow gastric emptying, and improve insulin sensitivity
Healthcare professionals managing such patients should document the rationale for both medications, monitor for adverse effects, and regularly review the necessity of continuing both treatments

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Anti-obesity medications are revolutioninising weight management Anti-obesity medications are placing new demands on the global food industry
Rita Machaalani at University of Sydney for her assistance on the measurement of Capase-3 and TUNEL expression