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Many acne medications initially cause dryness, peeling, flaking, redness, irritation and/or possibly acne flare-ups

The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation

Loren Pickart, who discovered GHK-Cu's skincare applications, found no additional benefit from concentrations above 3% and noted that higher concentrations may actually be counterproductive

[23] In more severe or prolonged cases of pernicious anemia, nerve cell damage may occur