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Continuous stimulation has been theorized to lead to receptor desensitization, whereas intermittent signaling may preserve responsiveness

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Follow-up of patients for more than 5 years revealed that only 53% of patients were free of disease, suggesting the importance of long-term follow-up [5]

While it is no secret that the cost of production of the drug molecule itself is only a small part of the retail price, the higher dosage required by oral delivery becomes a non-trivial difference in manufacturing costs

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