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Sweeney, M

Malonyl-CoA inhibits carnitine palmitoyl-transferase (CPT I), which transports fatty acyl-CoA into mitochondria where it is oxidised

Very low-calorie diets (800 kcal/day) may cause 35 pounds loss per week , but most of it is water and muscle, not fat , and its not sustainable

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Rybelsus has demonstrated cardiovascular safety in clinical trials, though it's worth noting that cardiovascular risk reduction is an established benefit for some injectable GLP-1 receptor agonists rather than an approved claim for oral semaglutide specifically