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Patients should maintain appropriate fluid intake based on individual needs, drinking to thirst and monitoring urine color (pale yellow indicates adequate hydration)

Complete appetite suppression is a normal pharmacological response to semaglutide's GLP-1 receptor activation

These unit costs were used to calculate annual costs of treatment for each arm, based on the resource use from the PIONEER 2 and 3 clinical trials for comparisons with empagliflozin and dulaglutide, respectively

Body weight and adiposity models: In diet-induced obesity (DIO) mouse models, retatrutide demonstrated pronounced effects on body weight trajectories over multi-week observation periods compared with vehicle controls

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