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So far preferential activation of GIPR activation, combined with less activation of GLP1R and even less activation of GR appear to have produced the most effective combination, as shown by Retatrutide, although whether this mixture is indeed the optimal is still an open question

Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision

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