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A notable research effort, known as the STEP (Semaglutide GLP-1 Treatment Effect in People with Obesity) trial, revealed that participants taking Semaglutide GLP-1 achieved an average weight reduction of around 15% of their starting body weight within 68 weeks, unlike those taking a placebo

Blood glucose monitoring : Although hypoglycaemia is uncommon with Ozempic monotherapy, it can occur when combined with insulin or sulphonylureas

While the increase in risk small, the association is statistically significant and worth exploring further

As GLP-1 treatment improves insulin sensitivity, this androgen excess reduces, and oestrogen-related hormonal balance often improves as a result

Elevated insulin blocks fat mobilization, rendering the peptide less effective