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Tardito, S
71 MochelF.DeLonlayP.TouatiG.BrunengraberH.KinmanR
On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes
In typical PINK1-Parkin-mediated mitophagy, damaged mitochondria encapsulated in autophagosomes depend on key membrane fusion factors, including Rab7, small GTPase-driven homotypic fusion, and the HOPS (homotypic fusion and vacuole protein sorting) complex, for docking and fusion with lysosomes [136, 137]
GSH deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of NFAT [nuclear factor of activated T cells] and Myc transcription factors, abrogating the energy utilization and Myc-dependent metabolic reprogramming that allows activated T cells to switch to glycolysis and glutaminolysis. Essentially, the researchers found that in the experimental mice, the control of viruses is impairedmice that lack the Gclc gene have an immunodeficiency
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