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De novo synthesis of serine from the glycolytic intermediate 3-phosphoglycerate (3-PG) occurs through a pathway consisting of three sequential steps: phosphoglycerate dehydrogenase (PHGDH) oxidizes 3-PG to 3-phosphohydroxypyruvate (pPYR) using an NAD + cofactor, phosphoserine aminotransferase (PSAT) transaminates pPYR to phosphoserine (pSER) using glutamate as the nitrogen donor, and finally phosphoserine phosphatase (PSPH) dephosphorylates pSER to produce serine [68]
Z., Nilsson, M., & Rungby, J
Tirzepatide dosing follows a similar escalation pattern from 2.5mg through 5mg, 7.5mg, 10mg, 12.5mg, and 15mg
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For all statistical tests, differences were considered significant at the 5% level
