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Supplemental Material Abbreviations cAMP cyclic AMP IR insulin receptor PKB protein kinase B PDE3B phosphodiesterase 3B AR adrenergic receptor HSL hormone-sensitive lipase AC adenylyl cyclase ODE ordinary differential equation
The results showed statistically significant but clinically modest weight loss (2kg average advantage over placebo at the 1mg oral dose over 23 weeks)
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Standard community protocols run retatrutide alone for the first 4 weeks at 1 mg weekly to confirm GI tolerance, then add MOTS-c at Week 5
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