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This dimerization appears to induce a switch in intracellular signaling cascades in which administration of a dopamine agonist (quinpirole) alone leads to a rapid increase in Ca 2+ levels, an effect not observed in preparations expressing D2R in the absence of GHSR1a (Kern et al., 2012)

Pituitary Response: The elevated cAMP levels and other intracellular signals stimulate the somatotroph cells to synthesize and release endogenous human growth hormone (hGH)

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