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Body composition may influence dosing requirements, though weight-based dosing has not been consistently employed in animal studies or limited human applications

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However, by virtue of stimulating the patient's immune white blood cells, ICI therapy sometimes causes serious side-effects that mimic autoimmune disease, including significant rash and/or inflammation of the thyroid, liver, lungs, nervous system, glandular system, heart, or other organs." The NCCN Guidelines for Patients are easy-to-understand, lay-language versions of the evidence-based, expert-consensus clinical practice guidelines used by health care providers all over the globe