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When insulin is not working well, blood sugar levels can become too high, leading to various health problems
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This realization set the stage for two parallel strategies that unfolded in the 1990s and 2000s: (1) development of injectable GLP-1 analogues resistant to degradation, and (2) development of DPP-4 inhibitors to protect and elevate native GLP-1 levels ( [44] )
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