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(c) nuclear translocation of predominantly p65/p50 dimers to induce transcription of target genes, including well-established FLICE-like inhibitory protein (c-FLIP) and apoptosis protein inhibitors (c-IAP)
An FXR agonist, obeticholic acid, is the first molecule to deliver a statistically significant improvement in one of the FDAs surrogate endpoints for accelerated approval of a treatment for NASH
doi:10.1016/j.smrv.2016.06.005
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