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Activation of the Nrf2 pathway was found to diminish liver injury due to iron overload by regulating the expression of Tf and FTH and reducing the accumulation of cellular iron-free ions, thereby inhibiting oxidative stress and attenuating cell death [47]
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Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans
high, 153 mm Hg) and subsequently randomized within each stratum to receive either riboflavin (1.6 mg/d) or placebo for 16 weeks
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