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However, the Look AHEAD trial and other studies examining intentional weight loss and cognition have shown variable results, suggesting this relationship is not straightforward

Apply step therapy and tie GLP-1 coverage to broader condition/change management programs for persistent change

Insoluble fiber requires more caution

This delayed emptying contributes to increased satiety and reduced appetite, which supports weight loss but can also produce gastrointestinal side effects

1 For those taking Wegovy pill, 76% achieved 5% or greater body weight loss (from a baseline body weight of 235 lb.) versus 31% taking placebo (from a baseline body weight of 231 lb.)